What Does “Fuck Up” Mean?

OK. Any of you guys who are friends on other forms of social media have probably already seen this, but I’m traveling and was working on other things, so this is my break-glass-in-case-of-emergency entry.

Please share this with any curious friends who are learning English, and if you have ideas for more lessons, please let me know in the comments. Or if you have a friend using cuss words incorrectly and you think I could give that pal a hand, tell me about the error and I’ll try not to fuck up explaining correct usage.